External Quality Assurance (EQA) Program for G6PD Quantitative Test in Philippines
Due to the COVID-19 pandemic, the scheduled shipping date of RH2020-02 survey has been changed. For the newly scheduled dates of RH2020-02 survey, please check [EQA Survey Schedule for 2020]
- 2020 External Quality Assurance (EQA) Program for G6PD Quantitative Test in Philippines [EQA Survey Schedule for 2020]
- Application Form for Changing Data in G6PD EQA MIS System
G6PD EQA MIS System:
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Glucose-6-phosphate dehydrogenase (G6PD; EC220.127.116.11; MIM305900) deficiency is the most common enzymopathic in humans. A relatively high incidence (>2%) of this enzymopathy, which may cause of neonatal jaundice and acute hemolytic anemia, was found in Southeast Asia. If it is not prevented or treated properly, neonatal jaundice may lead to kernicterus and cause death or permanent neurological damage. The life-threatening hemolytic crises that occur later may cause permanent kidney damage and can be induced by certain drugs or by eating fava beans. In order to reduce these complications, neonatal screening for G6PD deficiency has been carried out in many countries in this region.
In order to assure the reliability and consistence of the G6PD neonatal screening and confirmatory tests among different laboratories, an external quality assurance (EQA) program for screening G6PD activity in neonatal dried blood spots and determination of G6PD activity in hemolysate has been carried out in Taiwan since 1988 and adopted by the Philippines neonatal screening program (Screening test since 1999).
For the EQA survey on the confirmatory quantitative test (determination of G6PD activity in hemolysate), periodically, three lyophilized QC materials were sent to each participating laboratory on dry ice by speed post delivery. The results of G6PD activity analysis were requested to be returned by facsimile and submitted by internet within 8 days. The external QA results were evaluated and compared to the median of all reports received and the reference value determined by the reference laboratory. The summary report for each survey was published on website within two weeks after the survey started.
Instruction to External Quality Assurance (EQA) for G6PD Quantitative Test